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Table 2. Screening Adults for Lipid Disorders*

Study details LRC (34) HHS(35) WOSCOPS(36) AFCAPS(37)
Year 1984 1987 1995 1998
Duration (yr) 7.4 5 4.9 5.2
Intervention (dose) Cholestyramine (24g qd) Gemfibrozil (600 mg bid) Pravastatin (40 mg qd) Lovastatin (20-40 mg qd)
Inclusion Men with TC >265a and LDL 190b Healthy Finnish men (civil service or industrial employees); non-HDL [c] cholesterol>200 Men with "elevated LDL cholesterol" Men and women with average TC and below-average HDL
Age range for inclusion (yr) 35-59 40-55 45-64 Men, 45-73, Women, >55
Number of subjects, intervention/control 1906/1900 2051/2030 3302/3293 3304/3301
Mean age (yr) 48 47 55 58
   Male (%) 100 100 100 85
   White (%) 95.5 ~100 ~100 89
Mean BMI[d] (kg/m2) 26.25 26.6 26 27.05
Hypertension (%) 0 15 15 22
Mean TC start (mg/dL) 291.5 288.9 272 221
Mean LDL start (mg/dL) 215.5 NR[e] 192 150
Mean HDL start (mg/dL) 45 47 44 Men, 36; Women, 40
Current smokers (%) 38 36 44 12.5
Angina (5) 0 0 5 0
Diabetes 0 2.65 1 2.5
ASA[f] use (%) NR NR 3 17

*LRC, Lipids Research Council; HHS, Helsinki Heart Study; WOSCOPS, West of Scotland Coronary Prevention Study; AFCAPS, Air Force/Texas Coronary Atherosclerosis Prevention.

[a] TC indicates total cholesterol.
[b] LDL indicates low-density lipoprotein.
[c] HDL indicates high-density lipoprotein.
[d] BMI indicates body-mass index.
[e] NR indicates not reported.
[f] ASA indicates acetylsalicylic acid (aspirin).

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