Availability of Full Report
The full evidence report from which this summary was taken was prepared for the Agency for Healthcare Research and Quality (AHRQ) by the Tufts-New England Medical Center Evidence-based Practice Center, Boston, MA, under Contract No. 290-02-0022. Printed copies may be obtained free of charge from the AHRQ Publications Clearinghouse by calling 800-358-9295. Requesters should ask for Evidence Report/Technology Assessment No. 94, Effects of Omega-3 Fatty Acids on Cardiovascular Disease.
The Evidence Report is also online on the National Library of Medicine Bookshelf, or can be downloaded as a PDF File (2.2 MB). Plugin Software Help.
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1. Dyerberg J, Bang HO, Stoffersen E, et al. Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet 1978; 2(8081):117-9.
2. Bang HO, Dyerberg J, Sinclair HM. The composition of the Eskimo food in north western Greenland. Am J Clin Nutr 1980; 33(12):2657-61
3. NHANES III Series 11 No. 2A, April 1998. Electrocardiogram, Dietary Recall, Laboratory, Dietary Supplement and Prescription Drug. Available online at www.cdc.gov/nchs/about/major/nhanes/nh3data.htm. Accessed August 2003. National Center for Health Statistics. 1998.
4. NHANES III Series 11, No 3A, July 1999. Second Exam files for Dietary Recall, Examination, Laboratory, Additional Laboratory Analyses. Available online at www.cdc.gov/nchs/about/major/nhanes/nh3data.htm. Accessed August 2003. National Center for Health Statistics. 1999.
5. Marchioli R, Barzi F, Bomba E, et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione [see comments]. Circulation 2002; 105(16):1897-1903.
6. Nilsen DW, Albrektsen G, Landmark K, et al. Effects of a high-dose concentrate of n-3 fatty acids or corn oil introduced early after an acute myocardial infarction on serum triacylglycerol and HDL cholesterol. Am J Clin Nutr 2001; 74(1):50-6.
7. Leng GC, Lee AJ, Fowkes FG, et al. Randomized controlled trial of gamma-linolenic acid and eicosapentaenoic acid in peripheral arterial disease. Clin Nutr 1998; 17(6):265-71.
8. Sacks FM, Stone PH, Gibson CM, et al. Controlled trial of fish oil for regression of human coronary atherosclerosis. HARP Research Group. J Am Coll Cardiol 1995; 25(7):1492-8.
9. Singh RB, Niaz MA, Sharma JP, et al. Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival—4. Cardiovasc Drugs Ther 1997; 11(3):485-91.
10. Leren P. The effect of plasma cholesterol lowering diet in male survivors of myocardial infarction. A controlled clinical trial. Acta Medica Scandinavica—Supplementum 1966; 466:1-92.
11. de Lorgeril M, Salen P, Martin JL, et al. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study [see comments]. Circulation 1999; 99(6):779-85.
12. Singh RB, Dubnov G, Niaz MA, et al. Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial. Lancet 2002; 360(9344):1455-61.
13. Bemelmans WJ, Broer J, Feskens EJ, et al. Effect of an increased intake of alpha-linolenic acid and group nutritional education on cardiovascular risk factors: the Mediterranean Alpha-linolenic Enriched Groningen Dietary Intervention (MARGARIN) study. Am J Clin Nutr 2002; 75(2):221-27.
14. Leren P. The effect of plasma cholesterol lowering diet in male survivors of myocardial infarction. A controlled clinical trial. Acta Medica Scandinavica—Supplementum 1966; 466:1-92.
15. Burr ML, Ashfield-Watt PAL, Dunstan FDJ, et al. Lack of benefit of dietary advice to men with angina: results of a controlled trial. Eur J Clin Nutr 2003; 57(2):193-200.
16. Erkkila AT, Lehto S, Pyorala K, et al. n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease [comment]. Am J Clin Nutr 2003; 78(1):65-71.
17. Natvig H, Borchgrevink CF, Dedichen J, et al. A controlled trial of the effect of linolenic acid on incidence of coronary heart disease. The Norwegian vegetable oil experiment of 1965-66. Scandinavian Journal of Clinical & Laboratory Investigation—Supplement 1968; 105:1-20.
18. He K, Rimm EB, Merchant A, et al. Fish consumption and risk of stroke in men. JAMA 2002; 288(24):3130-6.
19. Albert CM, Hennekens CH, O'Donnell CJ, et al. Fish consumption and risk of sudden cardiac death. JAMA 1998; 279(1):23-8.
20. Mozaffarian DLR. Cardiac benefits of fish consumption may depend on the type of fish meal consumed: The Cardiovascular Health Study. Circulation 2003; 107(10):1372-7.
21. Siscovick DS, Raghunathan TE, King I, et al. Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. JAMA 1995; 274(17):1363-7.
22. Iso H, Rexrode KM, Stampfer MJ, et al. Intake of fish and omega-3 fatty acids and risk of stroke in women. JAMA 2001; 285(3):304-12.
23. Morris MC, Manson JE, Rosner B, et al. Fish consumption and cardiovascular disease in the physicians' health study: a prospective study. Am J Epidemiol 1995; 142(2):166-75.
24. Gillum RF, Mussolino ME, Madans JH. The relationship between fish consumption and stroke incidence. The NHANES I Epidemiologic Follow-up Study (National Health and Nutrition Examination Survey). Arch Intern Med 1996; 156(5):537-42.
25. Fraser GE, Strahan TM, Sabate J, et al. Effects of traditional coronary risk factors on rates of incident coronary events in a low-risk population. The Adventist Health Study. Circulation 1992; 86(2):406-13.
26. Osler M, Andreasen AH, Hoidrup S. No inverse association between fish consumption and risk of death from all-causes, and incidence of coronary heart disease in middle-aged, Danish adults. J Clin Epidemiol 2003; 56(3):274-9.
27. Nagata C, Takatsuka N, Shimizu H. Soy and fish oil intake and mortality in a Japanese community. Am J Epidemiol 2002; 156(9):824-31.
28. Djousse L, Pankow JS, Eckfeldt JH, et al. Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr 2001; 74(5):612-9.
29. Hu FB, Bronner L, Willett WC, et al. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA 2002; 287(14):1815-21.
30. Iso H, Stampfer MJ, Manson JE et al. Prospective study of fat and protein intake and risk of intraparenchymal hemorrhage in women. Circulation 2001; 103(6):856-63.
31. Fraser GE, Shavlik DJ. Risk factors for all-cause and coronary heart disease mortality in the oldest-old. The Adventist Health Study. Arch Intern Med 1997; 157(19):2249-58.
32. Iso H, Sato S, Umemura U, et al. Linoleic acid, other fatty acids, and the risk of stroke. Stroke 2002; 33(8):2086-93.
33. Hu FB, Willett WC. Optimal diets for prevention of coronary heart disease. JAMA 2002; 288(20):2569-78.
34. Dolecek TA. Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the multiple risk factor intervention trial. Proceedings of the Society for Experimental Biology & Medicine 1992; 200(2):177-82.
35. Hu FB, Stampfer MJ, Manson JE, et al. Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women. Am J Clin Nutr 1999; 69(5):890-7.
36. Ness AR, Hughes J, Elwood PC, et al. The long-term effect of dietary advice in men with coronary disease: follow-up of the diet and reinfarction trial (DART). Eur J Clin Nutr 2002; 56(6):512-8.
37. Burr ML, Fehily AM, Rogers S, et al. Diet and reinfarction trial (DART): design, recruitment, and compliance. Eur Heart J 1989; 10(6):558-67.
38. Burr ML, Fehily AM, Gilbert JF, et al. Effects of changes in fat, fish, and fiber intakes on death and myocardial reinfarction: diet and reinfarction trial (DART) [see comments]. Lancet 1989; 2(8666):757-61
39. Eritsland J. Safety considerations of polyunsaturated fatty acids. Am J Clin Nutr 2000; 71(1 suppl.):197S-201S.
40. Reis GJ, Boucher TM, Sipperly ME, et al. Randomised trial of fish oil for prevention of restenosis after coronary angioplasty. Lancet 1989; 2(8656):177-81.
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AHRQ Publication Number 04-E009-1
Current as of March 2004