Technology Assessment: Report on the Relative Efficacy of Oral Cancer Therapy for Medicare Beneficiaries Versus Currently Covered Therapy, Part 3. Imatinib for Chronic Myeloid Leukemia (CML). Figure 2

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Report on the Relative Efficacy of Oral Cancer Therapy for Medicare Beneficiaries Versus Currently Covered Therapy

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Figure 2: Phases of CML¹⁹

Phase	Clinical Characteristics	Median duration
Chronic phase	< 15% blasts and promyelocytes in the peripheral blood and bone marrow	3-5 years
Accelerated phase	> 15% to < 30% blasts in either the peripheral blood or bone marrow	6-18 months
Blastic phase	> 30% blasts in the peripheral blood or bone marrow (some authors use this term interchangeably with "blast crisis")	3-6 months
Blast crisis	> 30% blasts are present in the face of fever, malaise, and progressive splenomegaly; blast crisis is a subset of blast phase (some authors use this term interchangeably with "blastic phase")
Relapse	Any evidence of progression of disease from a stable remission, which may include increased myeloid or blast cells in the peripheral blood or bone marrow, cytogenetic positivity for BCR-ABL when previously cytogenetic negative, or FISH positivity for BCR-ABL when previously FISH negative. (Note that detection of BCR-ABL by RT-PCR during prolonged remissions does not constitute relapse on its own)

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Figure 2: Phases of CML19

Figure 2: Phases of CML¹⁹