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|Complete hematologic remission
||Normal complete blood count and normal physical examination
|Reported as Complete Hematologic Response (CHR)
|| Complete HR
||Normal complete blood count and exam
| Partial HR
||Improved but not normal complete blood count and exam
||Complete plus partial hematologic response
|Complete cytogenetic remission
||Normal chromosome examination with no Ph-positive cells detectable on
metaphase cytogenetic of bone marrow with 20-25 cells analyzed
|Reported as Complete Cytogenetic Response (CCR)2
|| Complete CR
||0% Ph positive cells detectable
| Partial CR
||1-34% Ph positive cells detectable
| Major CR (= Complete CR plus Partial CR)
||<35% Ph positive cells detectable
| Minor CR
||35-65% Ph positive cells detected*
| Minimal CR
||66-95% Ph positive cells detected
| No CR
||>95% Ph positive cells detected
||Negative RT-PCR evidence of the BCR-ABL mRNA
|Variably reported as Complete Molecular Response (CMR)
|| Complete MR
||No detectable BCR-ABL mRNA
| Major MR
||> 3 log reduction in detectable BCR-ABL mRNA33
|Overall survival (OS)
||The percentage of CML subjects in a study who have survived for a defined
period of time. Usually reported as time since diagnosis or treatment.
|Time to progression (TTP)
||A measure of time after CML is diagnosed (or treated) until it starts
to get worse.
|Progression-free survival (PFS)
||The probability that a CML patient will remain alive, without the disease
|Disease-free survival (DFS)
||Length of time after treatment during which no CML is found. Can be reported
for an individual patient or for a study population.
|Event-free survival (EFS)
||Length of time after treatment that a CML participant in a clinical study
remains free of pre-defined events. Events are defined by the study and
can include adverse treatment effects, CML relapse/progression, or survival.
||The percentage of people in a study or treatment group who are alive
for a given period of time after diagnosis. Commonly expressed as 1-year,
2-year, 5-year, and 10-year survival.