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Figure 6: The CML Therapy Matrix with Complete CR Estimates
| Previous Therapy |
Phase |
|---|
| Chronic phase |
Accelerated phase |
Blastic phase/blast crisis |
| Extent of Previous Therapy |
Newly diagnosed |
Phase III:
I: 74%59
IFN + AraC:
9%,59 15%42
IFN alone: 9%42
Phase II:
I 60-81%63,98
Historical control (includes IFN):
5-32%63,98 |
I: 11-19%82,87
Estimated IFN: <5% |
I: 0-10%3,4,89,90
Estimated IFN: <<5% |
| Interferon refractory or intolerant |
I: 31-62%2,44,73,148
Historical control with IFN: 7-19%44 |
I: 11-19%82,87
Estimated IFN: <5% |
I: 0-10%3,4,89,90
Estimated IFN: <<5% |
| Previous stem cell transplant/heavily pretreated |
I: 33-85%37,77-81 Historical
control with IFN: 7-19%44 (from above) |
I: 11-19%82,87
Estimated IFN: <5% |
I: 0-10%3,4,89,90
Estimated IFN: <<5% |
| Imatinib refractory or intolerant |
Future Directions |
Future Directions |
Future Directions |
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