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Report on the Relative Efficacy of Oral Cancer Therapy for Medicare Beneficiaries Versus Currently Covered Therapy

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Part 3. Imatinib for Chronic Myeloid Leukemia (CML) (continued)


Included Articles

1. Al-Ali HK, Krahl R, Orth M, et al. Persistently increased creatine kinase levels in patients with chronic myeloid leukemia treated with imatinib correlate with major cytogenetic remission. Blood 2004;104(11):Abstract #2933.

2. Albitar M, Cortes J, Giles F, et al. Molecular monitoring of chronic phase chronic myeloid leukemia patients treated with 800mg imatinib. Journal of Clinical Oncology 2005;23:Abstract 6554.

3. American Cancer Society. Cancer Facts and Figures 2005. http://www.cancer.org/docroot/STT/stt_0.asp. Accessed March 25.

4. Anonymous. Interferon alfa versus chemotherapy for chronic myeloid leukemia: a meta-analysis of seven randomized trials: Chronic Myeloid Leukemia Trialists' Collaborative Group. Journal of the National Cancer Institute 1997;89(21):1616-20.

5. Baccarani M, Martinelli G, Rosti G, et al. Imatinib and pegylated human recombinant interferon-{alpha}2b in early chronic-phase chronic myeloid leukemia. Blood 2004;104(13):4245-51.

6. Baccarani M, Rosti G, de Vivo A, et al. Arandomized study of interferon-a versus interferon-a and low-dose arabinosyl cytosine in chronic myeloid leukemia. Blood 2002;99:527-1535.

7. Bacik J, Mazumdar M, Murphy B, et al. The functional assessment of cancer therapy-BRM (FACT-BRM): A new tool for the assessment of quality of life in patients treated with biologic response modifiers. Quality of Life Research 2004;13(1):137-54.

8. Barrett A, Malkovska V. Graft-versus-leukaemia: understanding and using the alloimmune response to treat haematological malignancies. British Journal of Haematology 1996;93. 1996:754-61.

9. Bassi S, Castagnetti F, Amabile M, et al. Imatinib in the treatment of CML patients >65 years old in late chronic phase: Results of a phase II study of the GIMEMA CML Working Party. Blood 2004;104(11):Abstract #2935.

10. Berger U, Hochhaus A, Reiter A, et al. Feasibility of imatinib combination therapies in a randomized trial for chronic myeloid leukemia: The German CML-Study IV-Pilot Phase. Blood 2004;104(11):Abstract #24.

11. Bhatia R., Holtz M., Niu N., et al. Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood 2003;101(12):4701-7.

12. Bose S, Deininger MW, Gora-Tybor J, et al. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: Biologic significance and implications for the assessment of minimal residual disease. Blood 92. 1998.

13. Branford S, Rudzki Z, Grigg A, et al. The frequency of detection of BCR-ABL mutations in imatinib treated patients with chronic phase CML who attain a complete cytogenetic response (CCR) does not diminish with increasing duration of ccr but the associated loss of response is usually gradual. Blood 2004;104(11):Abstract #271.

14. Branford S, Rudzki Z, Grigg A, et al. BCR-ABL levels continue to decrease up to 42 months after commencement of standard dose imatinib in patients with newly diagnosed chronic phase CML who achieve a major molecular response. Blood 2004;104(11):Abstract #274.

15. Branford S, Rudzki Z, Harper A, et al. Imatinib produces significantly superior molecular responses compared to interferon alfa plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Leukemia 2003;17(12):2401-9.

16. Branford S, Rudzki Z, Parkinson I, et al. Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CMLtreated with imatinib who have BCR-ABL kinase domain mutations. Blood 2004;104(9):2926-32.

17. Braziel RM, Launder TM, Druker BJ, et al. Hematopathologic and cytogenetic findings in imatinib mesylate-treated chronic myelogenous leukemia patients: 14 months' experience. Blood 2002;100(2):435-41.

18. Ceglarek BB, Konopka LJ, Sikorska A, et al. Gleevec Therapy in Advanced Phases of the CML-Polish Study Report. Blood 2004;104(11):Abstract #4701.

19. Cervantes F, Hernandez-Boluda JC, Odriozola J, et al. Imatinib mesylate (STI571) treatment in patients with chronic-phase chronic myelogenous leukaemia previously submitted to autologous stem cell transplantation. British Journal of Haematology 2003;120(3):500-4.

20. Cohen MH, Johnson JR, Pazdur R. U.S. Food and Drug Administration Drug Approval Summary: Conversion of Imatinib Mesylate (STI571; Gleevec) Tablets from Accelerated Approval to Full Approval. Clinical Cancer Research 2005;11:12-9.

21. Cohen MH, Williams G, Johnson JR, et al. Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia. Clinical Cancer Research 2002;8(5):935-42.

22. Conneally E, Carroll P, Neat M, et al. Imatinib mesylate treatment of patients with chronic myeloid leukaemia relapsing following allogeneic stem cell transplantation. Blood 2004;104(11):Abstract #4659.

23. Corm S, Nicollini F, Borie D, et al. Mutation status of imatinib mesylate-resistants cml patients and clinical outcomes: A French multicenter retrospective study for the fiLMC Group. Blood 2004;104(11):Abstract #275.

24. Cornelissen JJ, Valk P, Verhoef GEG, et al. High rates of molecular response and low incidence of mutations in patients treated with newly diagnosed chronic myeloid leukemia (CML) treated with a dose-escalated combination of imatinib and cytarabin. Blood 2004;104(11):Abstract #19.

25. Corsetti MT, Beltrami G, Carella AM. Imatinib achieves high rates of complete citogenetic remission (CCR) in CML patients relapsed after autografting and IFN-a Therapy. Blood 2004;104(11):Abstract #4656.

26. Cortes J, Giles F, O'Brien S, et al. Result of high-dose imatinib mesylate in patients with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon-alpha. Blood 2003;102(1):83-6.

27. Cortes J, Giles F, Salvado A, et al. High dose (HD) imatinib in patients with previously untreated chronic myeloid leukemia (CML) in early chronic phase (CP): preliminary results of a multicenter community based trial. Journal of Clinical Oncology 2005;20(162):abstract 6518.

28. Cortes J, Talpaz M, Beran M, et al. Philadelphia chromosome-negative chronic myelogenous leukemia with rearrangement of the breakpoint cluster region. Long-term follow-up results. Cancer 1995 Jan 15;75. 1995:464-70.

29. Cortes J, Talpaz M, Giles F, et al. Prognostic significance of cytogenetic clonal evolution in patients with chronic myelogenous leukemia on imatinib mesylate therapy. Blood 2003;101(10):3794-800.

30. Cortes J, Talpaz M, O'Brien S, et al. Survival advantage for patients (pts) with chronic myeloid leukemia (CML) in accelerated phase (AP) treated with imatinib. Blood 2004;104(11):Abstract #1006.

31. Cortes J, Talpaz M, O'Brien S, et al. High-dose imatinib mesylate treatment in patients (pts) with previously untreated early chronic phase (CP) chronic myeloid leukemia (CML). Blood 2004;104(11):Abstract #999.

32. Cortes J, Talpaz M, O'Brien S, et al. Clinical significance of molecular monitoring in chronic myeloid leukemia (CML) in chronic phase (CP) with imatinib therapy. Blood 2004;104(11):Abstract #272.

33. Crossman LC, Druker BJ, Deininger MW. hOCT 1 and resistance to imatinib. Blood 2005;106(3):1133-4.

34. Crossman LC, Mori M, Hsieh Y, et al. In chronic myeloid leukemia white cells from cytogenetic responders and non-responders to imatinib have very similar gene expression signatures. Haematologica 2005;90:459-64.

35. Deininger MW, Willis S, Lange T, et al. Detection of imatinib-resistant BCR-ABL mutants in drug-naïve patients: correlation with disease phase and clonal evolution but not with response to treatment. Blood 2004;104(11):Abstract #273.

36. Deshmukh CD, Saikia T, Bakshi AV, et al. Imatinib mesylate in chronic myeloid leukemia (CML): A single institution experience of 174 patients. Journal of Clinical Oncology 2004;22(14S):Abstract #6710.

37. Druker BJ. Taking aim at Ewing's sarcoma: is KIT a target and will imatinib work? Journal of the National Cancer Institute 2002;94(22):1660-1.

38. Druker BJ, Sawyers CL, Kantarjian H, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. New England Journal of Medicine 2001;344(14):1038-42.

39. Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. New England Journal of Medicine 2001;344(14):1031-7.

40. Drummond A, Micallef-Eynaud P, Douglas WS, et al. A spectrum of skin reactions caused by the tyrosine kinase inhibitor imatinib mesylate (STI 571, Glivec). British Journal of Haematology 2003;120(5):911-3.

41. El-Zimaity MM, Kantarjian H, Talpaz M, et al. Results of imatinib mesylate therapy in chronic myelogenous leukaemia with variant Philadelphia chromosome. British Journal of Haematology 2004;125(2):187-95.

42. Elliot VJ, Marin D, Horncastle D, et al. Total number of CD34 + cells per ten high power fields in bone marrow trephines of patients with chronic myeloid leukaemia correlates with probability of complete cytogenetic response during the first year of treatment with imatinib. Blood 2004;104(11):Abstract #4664.

43. Faderl S, Talpaz M, Estrov Z, et al. Chronic Myelogenous leukemia: biology and therapy. Annals of Internal Medicine 1999;131(3):207-19.

44. Fischer T, Reifenrath C, Hess GR, et al. Safety and efficacy of STI-571 (imatinib mesylate) in patients with bcr/abl-positive chronic myelogenous leukemia (CML) after autologous peripheral Blood stem cell transplantation (PBSCT). Leukemia 2002;16(7):1220-8.

45. Frater JL, Tallman MS, Variakojis D, et al. Chronic myeloid leukemia following therapy with imatinib mesylate (Gleevec). Bone marrow histopathology and correlation with genetic status. American Journal of Clinical Pathology 2003;119(6):833-41.

46. Fruehauf, Topaly, Buss EC, et al. A multicenter phase I/II trial of the combination of imatinib mesylate with mitoxantrone/etoposide and cytarabine in patients with CML in myeloid blast crisis: a trend to a longer survival in patients receiving more aggressive treatment schedules. Blood 2004;104(11):Abstract #2929.

47. Gardembas M, Rousselot P, Tulliez M, et al. Results of a prospective phase 2 study combining imatinib mesylate and cytarabine for the treatment of Philadelphia-positive patients with chronic myelogenous leukemia in chronic phase. Blood 2003;102(13):4298-305.

48. George S, Horvath L, Molokie R, et al. Response to therapy with imatinib mesylate in patients with CML is poor in non-caucasian patients. Blood 2004;104(11):Abstract #2937.

49. Goldman J. M. , Melo J. V. Mechanisms of disease - Chronic myeloid leukemia - Advances in biology and new approaches to treatment. New England Journal of Medicine 2003;349(15):1451-64.

50. Gorre ME, Skaggs BJ, Sawyers CL. Imatinib-resistant BCR-ABL mutations alter oncogenic potency, kinase activity and substrate selection. Blood 2004;104(11):Abstract #556.

51. Gratwohl A, Hermans J. Allogeneic bone marrow transplantation for chronic myeloid leukemia. Working Party Chronic Leukemia of the European Group for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplantation 17 (Suppl 3):S7-9.

52. Guilhot F. Sustained durability of responses plus high rates of cytogenetic responses result in long-term benefit for newly diagnosed chronic-phase chronic myeloid leukemia (CML-CP) treated with imatinib (IM) therapy: update from the IRIS study. Blood 2004;104(11):Abstract #21.

53. Guilhot F, Chastang C, Michallet M, et al. Interferon alfa-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia. French Chronic Myeloid Leukemia Study Group. New England Journal of Medicine 1997;337(4):223-9.

54. Hahn EA, Glendenning GA. Quality of life on imatinib. Seminars in Hematology 2003;40(2 Suppl 2):31-6.

55. Hahn EA, Glendenning GA, Sorensen MV, et al. Quality of life in patients with newly diagnosed chronic phase chronic myeloid leukemia on imatinib versus interferon alfa plus low-dose cytarabine: results from the IRIS Study. Journal of Clinical Oncology 2003;21(11):2138-46.

56. Hasford J, Pfirrmann M, Hehlmann R, et al. A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. Writing Committee for the Collaborative CML Prognostic Factors Project Group. Journal of the National Cancer Institute 1998;90:850-8.

57. Hehlmann R, Heimpel H, Hasford J, et al. Randomized comparison of busulfan and hydroxyurea in chronic myelogenous leukemia: prolongation of survival by hydroxyurea. The German CML Study Group. Blood 1993;82(2):398-407.

58. Hehlmann R, Hochhaus A, Berger U, et al. Concept and feasibility of the randomized comparison of imatinib with imatinib combination therapies for chronic myeloid leukemia: the German CML Study IV-Pilot Phase. Journal of Clinical Oncology 2005;23(16S):Abstract #6574.

59. Hess G, Bunjes D, Siegert W, et al. Durable molecular remissions in patients with relapsed CML post allogeneic stem cell transplantation upon treatment with imatinib-mesylate (Glivec®, STI-571). Follow-up results of a phase II open-label study. Blood 2004;104(11):Abstract #1004.

60. Hochhaus A. Imatinib mesylate (Glivec, Gleevec) in the treatment of chronic myelogenous leukemia (CML) and gastrointestinal stromal tumors (GIST). Annals of Hematology 2004;83(Suppl 1):S65-6.

61. Hochhaus A, Kreil S, Corbin AS, et al. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 2002;16(11):2190-6.

62. Hughes T, Branford S, Reynolds J, et al. Higher-dose imatinib (600 mg/day) with selective intensification in newly diagnosed CML patients in chronic phase; cytogenetic response rates at 12 months are superior to IRIS. Blood 2004;104(11):Abstract #1001.

63. Hughes TP, Kaeda J, Branford S, et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. New England Journal of Medicine 2003;349(15):1423-32.

64. Huntly B, Bench A, Delabesse E, et al. Derivative chromosome 9 deletions in chronic myeloid leukemia: poor prognosis is not associated with loss of ABL-BCR expression, elevated BCR-ABL levels, or karyotypic instability. Blood 2002;99(12):4547-53.

65. Huntly B, Guilhot F, Reid A, et al. Imatinib improves but may not fully reverse the poor prognosis of patients with CML with derivative chromosome 9 deletions. Blood 2003;102(6):2205-12.

66. Huntly B, Reid A, Bench A, et al. Deletions of the derivative chromosome 9 occur at the time of the Philadelphia translocation and provide a powerful and independent prognostic indicator in chronic myeloid leukemia. Blood 2001;98(6):1732-8.

67. Huntly BBA, Green A. Double jeopardy from a single translocation: deletions of the derivative chromosome 9 in chronic myeloid leukemia. Blood 2003;102(4):1160-8.

68. Issa S, Holdsworth D, Oei P, et al. The utility of peripheral Blood FISH in the quantitation of BCR/ABL in CML patients on imatinib mesylate: a comparison with bone marrow FISH and conventional cytogenetics. Blood 2004;104(11):Abstract #2942.

69. Jabbour E, Kantarjian H, Jones D, et al. Long-term incidence and outcome of BCR-ABL mutations in patients (pts) with chronic myeloid leukemia (CML) treated with imatinib mesylate. P-Loop mutations are not associated with worse outcome. Blood 2004;104(11):Abstract #1007.

70. Johansson B, Fioretos T, Mitelman F. Cytogenetic and molecular genetic evolution of chronic myeloid leukemia. Acta Haematologica 2002;107(2):76-94.

71. Johnson JR, Bross P, Cohen M, et al. Approval summary: imatinib mesylate capsules for treatment of adult patients with newly diagnosed philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase. Clinical Cancer Research 2003;9(6):1972-9.

72. Kagami Y, Katagiri T, Kaneta Y, et al. Validation study on the prediction of response to imatinib mesylate in chronic myeloid leukemia (CML) patients by genome-wide cDNA microarray analysis. Blood 2004;104(11):Abstract #2946.

73. Kaneta Y, Kagami YKT, Tsunoda T, et al. Prediction of sensitivity to STI571 among chronic myeloid leukemia patients by genome-wide cDNA microarray analysis. Japanese Journal of Cancer Research 2002;93:849–856.

74. Kantarjian H, Cortes J, O'Brien S, et al. Long-term survival benefit and improved complete cytogenetic and molecular response rates with imatinib mesylate in Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia after failure of interferon-alpha. Blood 2004;104(7):1979-88.

75. Kantarjian H, Cortes J, O'Brien S, et al. Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase. Blood 2002;99(10):3547-53.

76. Kantarjian H, Cortes J, O'Brien S, et al. Imatinib mesylate therapy in newly diagnosed patients with Philadelphia chromosome-positive chronic myelogenous leukemia: high incidence of early complete and major cytogenetic responses. Blood 2003;101(1):97-100.

77. Kantarjian H, Deisseroth A, Kurzrock R, et al. Chronic myelogenous leukemia: a concise update. Blood 1993;82(3):691-703.

78. Kantarjian H, Dixon D, Keating M, et al. Characteristics of accelerated disease in chronic myelogenous leukemia. Cancer 1988;61(7):1441-6.

79. Kantarjian H, Keating M, Estey E, et al. Treatment of advanced stages of Philadelphia chromosome-positive chronic myelogenous leukemia with interferon-ei and low-dose cytarabine. Journal of Clinical Oncology 1992;10(5):772-8.

80. Kantarjian H, O'Brien S, Cortes J, et al. Complete cytogenetic and molecular responses to interferon-alpha-based therapy for chronic myelogenous leukemia are associated with excellent long-term prognosis. Cancer 2003;94(7):1033-41.

81. Kantarjian H, O'Brien S, Cortes J, et al. Imatinib mesylate therapy improves survival in patients with newly diagnosed Philadelphia chromosome-positive chronic myelogenous leukemia in the chronic phase: comparison with historic data. Cancer 2003;98(12):2636-42.

82. Kantarjian H, O'Brien S, Cortes J, et al. Survival advantage with imatinib mesylate therapy in chronic-phase chronic myelogenous leukemia (CML-CP) after IFN-alpha failure and in late CML-CP, comparison with historical controls. Clinical Cancer Research 2004;10(1 Pt 1):68-75.

83. Kantarjian H, O'Brien S, Cortes J, et al. Imatinib mesylate therapy for relapse after allogeneic stem cell transplantation for chronic myelogenous leukemia. Blood 2002;100(5):1590-5.

84. Kantarjian H, Sawyers C, Hochhaus A, et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. New England Journal of Medicine 2002;346(9):645-52.

85. Kantarjian H, Talpaz M, O'Brien S, et al. Imatinib mesylate for Philadelphia chromosome-positive, chronic-phase myeloid leukemia after failure of interferon-alpha: follow-up results. Clinical Cancer Research 2002;8(7):2177-87.

86. Kantarjian H, Talpaz M, O'Brien S, et al. High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia. Blood 2004;103(8):2873-8.

87. Kantarjian H, Talpaz M, O'Brien S, et al. Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia. Blood 2003;101(2):473-5.

88. Kurzrock R, Gutterman J, Talpaz M. The molecular genetics of Philadelphia chromosome-positive leukemias. New England Journal of Medicine 1988;319(15):990-8.

89. Kvasnicka HM, Thiele J, Staib P, et al. Reversal of bone marrow angiogenesis in chronic myeloid leukemia following imatinib mesylate (STI571) therapy. Blood 2004;103(9):3549-51.

90. Lahaye T, Riehm B, Berger U, et al. Response and resistance in 300 patients with BCR-ABL–positive leukemias treated with imatinib in a single center: a 4.5-year follow-up. Cancer 2005;103(8):1659-69.

91. Lange T, Bumm T, Mueller M, et al. Durability of molecular remission in chronic myeloid leukemia patients treated with imatinib vs allogeneic stem cell transplantation. Leukemia 2005;19:1262-9.

92. Lange T, Bumm T, Mueller M, et al. Molecular remission to imatinib in patients with chronic myeloid leukaemia (CML) is less durable compared to patients after allografting. Blood 2004;104(11):Abstract #276.

93. Lange T, Gunther C, Kohler T, et al. High levels of BAX, low levels of MRP-1, and high platelets are independent predictors of response to imatinib in myeloid blast crisis of CML. Blood 2003;101(6):2152-5.

94. Laurence A, Marin D, Clark R, et al. Frequency of blast crisis after achieving complete cytogenetic remission in first chronic phase CML patients who received imatinib therapy within six months of diagnosis. Blood 2004;104(11):Abstract #1021.

95. Le Coutre P, Kreuzer KA, Na IK, et al. Imatinib in Philadelphia chromosome-positive chronic phase CML patients: molecular and cytogenetic response rates and prediction of clinical outcome. American Journal of Hematology 2003;73(4):249-55.

96. Lee S, Anasetti C, Horowitz M, et al. Initial therapy for chronic myelogenous leukemia: playing the odds. Journal of Clinical Oncology 1998;16(9):2897-903.

97. Marin D, Goldman JM, Olavarria E, et al. Transient benefit only from increasing the imatinib dose in CML patients who do not achieve complete cytogenetic remissions on conventional doses. Blood 2003;102(7):2702-4.

98. Marin D, Horncastle D, Andreasson C, et al. Prognostic impact of percentage cd34 expression in bone marrow trephines of patients with chronic myeloid leukaemia in chronic phase treated with imatinib. Blood 2004;104(11):Abstract #1019.

99. Marin D, Marktel S, Bua M, et al. Prognostic factors for patients with chronic myeloid leukaemia in chronic phase treated with imatinib mesylate after failure of interferon alfa. Leukemia 2003;17(8):1448-53.

100. Marin D, Marktel S, Szydlo R, et al. Survival of patients with chronic-phase chronic myeloid leukaemia on imatinib after failure on interferon alfa. Lancet 2003;362:617-9.

101. Marktel S, Marin D, Foot N, et al. Chronic myeloid leukemia in chronic phase responding to imatinib: the occurrence of additional cytogenetic abnormalities predicts disease progression. Haematologica 2003;88(3):260-7.

102. Martiat P, Michaux J, Rodhain J. Philadelphia-negative (Ph-) chronic myeloid leukemia (CML): comparison with Ph+ CML and chronic myelomonocytic leukemia. The Groupe Francais de Cytogenetique Hematologique. Blood 1991;78(1):205-11.

103. Martino B, Vincelli Y, Ronco F, et al. Efficacy and safety of imatinib treatment in elderly patients with chronic myeloid leukemia. Blood 2004;104(11):Abstract #4680.

104. McLean LA, Gathmann I, Capdeville R, et al. Pharmacogenomic analysis of cytogenetic response in chronic myeloid leukemia patients treated with imatinib. Clinical Cancer Research 2004;10(1 Pt 1):155-65.

105. Merx K, Muller MC, Kreil S, et al. Early reduction of BCR-ABL mRNA transcript levels predicts cytogenetic response in chronic phase CML patients treated with imatinib after failure of interferon alpha. Leukemia 2002;16(9):1579-83.

106. Monroy RH, Vargas-Viveros P, Cervera E, et al. Imatinib Alone (IA) vs. Imatinib + Ara-C (IMAC): A randomized phase III clinical trial for the treatment of early phase (EP) chronic myeloid leukemia (CML) Ph+. Preliminary report of Mexican Cooperative Leukemia Group (GRUMELA). Blood 2004;104(11):Abstract #1015.

107. Moravcova J, Zmekova V, Klamova H, et al. Differences and similarities in kinetics of BCR-ABL transcript levels in CML patients treated with imatinib mesylate for chronic or accelerated disease phase. Leukemia Research 2004;28(4):415-9.

108. Müller MC, Gattermann N, Lahaye T, et al. Dynamics of BCR-ABL mRNA expression in first-line therapy of chronic myelogenous leukemia patients with imatinib or interferon alpha/ara-C. Leukemia 2003;17(12):2392-400.

109. Müller MC, Paschka P, LaHaye T, et al. Molecular long-term surveillance of CML patients on imatinib therapy. Follow-up of German patients treated within the IRIS trial. Blood 2004;104(11):Abstract #1003.

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112. National Institute for Clinical Excellence. Guidance on the use of imatinib for chronic myeloid leukaemia. London: National Institute for Clinical Excellence (NICE); 2003.

113. O'Brien S, Giles F, Talpaz M, et al. Results of triple therapy with interferon-alpha, cytarabine, and homoharringtonine, and the impact of adding imatinib to the treatment sequence in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in early chronic phase. Cancer 2003;98(5):888-93.

114. O'Brien S, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. New England Journal of Medicine 2003;348(11):994-1004.

115. O'Brien S, Tefferi A, Valent P. Chronic myelogenous leukemia and myeloproliferative disease. 2004.

116. O'Dwyer ME, Gatter KM, Loriaux M, et al. Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate. Leukemia 2003;17(3):481-7.

117. O'Dwyer ME, Mauro MJ, Blasdel C, et al. Clonal evolution and lack of cytogenetic response are adverse prognostic factors for hematologic relapse of chronic phase CML patients treated with imatinib mesylate. Blood 2004;103(2):451-5.

118. Olavarria E, Ottmann OG, Deininger MW, et al. Response to imatinib in patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukemia. Leukemia 2003;17(9):1707-12.

119. Onida F, Ball G, Kantarjian H, et al. Characteristics and outcome of patients with Philadelphia chromosome negative, BCR/ABL negative chronic myelogenous leukemia. Cancer 2002;95(8):1673-84.

120. Palandri F, Martinelli G, Amabile M, et al. Imatinib therapy for chronic myeloid leukemia patients who relapse after allogeneic stem cell transplantation: a molecular analysis. Blood 2004;104(11):Abstract #4655.

121. Paschka P, Branford S, Lorentz C, et al. Comparison of "log reduction from median pretherapeutic value" vs ratio BCR-ABL/ABL to express the therapeutic response in CML patients. Blood 2004;104(11):Abstract #1013.

122. Paschka P, Muller MC, Merx K, et al. Molecular monitoring of response to imatinib (Glivec) in CML patients pretreated with interferon alpha. Low levels of residual disease are associated with continuous remission. Leukemia 2003;17(9):1687-94.

123. Pasquini R, Clementino NC, Zanichelli MA, et al. Observational study for evaluation of quality of life in patients with chronic myeloid leukemia (CML) in use of Gleevec® (imatinib mesilate). Blood 2004;104(11):Abstract #2932.

124. Pautas C, Nicolini F, Cony-Makhoul P, et al. Imatinib mesylate (IM), is an alternative to donor lymphocyte infusion (DLI) for chronic myelogenous leukemia (CML) in relapse after allogeneic stem cell transplantation: a 3-year follow-up report, on the Behalf of the Société Française de Greffe de Moëlle et de Thérapie Cellulaire (SFGM-TC) and the France Intergroupe de la Leucémie Myéloïde Chronique (Fi-LMC). Blood 2004;104(11):Abstract #1017.

125. Press RD, Love Z, Tronnes AA, et al. BCR-ABL RNA levels at the time of a complete cytogenetic response (CCR) predict the duration of CCR in imatinib-treated chronic myeloid leukemia patients. Blood 2004;104(11):Abstract #1098.

126. Quintas-Cardama A, Kantarjian H, Talpaz M, et al. Imatinib mesylate therapy may overcome the poor prognostic significance of deletions of derivative chromosome 9 in patients with chronic myelogenous leukemia. Blood 2005;105(6):2281-6.

127. Radich J, Gooley T, Bensinger W, et al. HLA-matched related hematopoietic cell transplantation for chronic-phase CML using a targeted busulfan and cyclophosphamide preparative regimen. Blood 2003;102(1):31-5.

128. Robinson KA, Dickersin K. Development of a highly sensitive search strategy for the retrieval of reports of controlled trials using PubMed. International Journal of Epidemiology 2002;31(1):150-3.

129. Rosti G, Martinelli G, Bassi S, et al. Molecular response to imatinib in late chronic-phase chronic myeloid leukemia. Blood 2004;103(6):2284-90.

130. Rousselot P, Legros L, Guilhot J, et al. A Phase I/II dose escalating study of daunorubicin combined with imatinib mesylate and cytarabine as induction therapy for chronic myelogenous leukaemia in myeloid blast crisis. Preliminary results of the AFR01 trial. Blood 2004;104(11):Abstract #1002.

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