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| Prognostic factor |
Studies indicating an association and quality |
Strength of association with tumor response |
Strength of association with survival |
| Cytogenetic response to imatinib |
Marin, Marktel, Szydlo, et al., 200368
(Quality 5/5)
CP-IFN-r |
Achieved at least a minor CR with I:
RR for PFS = 0.09 (CI 0.03-0.25, p<0.0001)
No cytogenetic response with I:
RR for OS = 1.94 (CI 1.22-3.01, p=0.0053) |
Achieved at least a minor CR with I:
RR for OS = 0.13 (CI 0.05-0.39, p=0.0002)
No cytogenetic response with I:
RR for OS = 1.69 (CI 1.09-2.64, p=0.02)
Adjusted probabilities of OS at 8 years were 78% (CI 51-93%) for responders,
23% (CI 18-29%) for IFN refractory historical controls not getting I, and
6% (CI 2-17%) for non-responders |
O'Dwyer, 200496
(Quality 2/5)
CP-IFN-r |
Relationship of MCR to hemotologic relapse:
No MCR: N= 77 26%
p=0.0339
MCR: N = 64 3%
HR 0.193 (CI 0.042-0.883) |
|
Rosti, 20048
(Quality 4/5)
CP |
|
Achieved at least a MCR with I:
OS estimated from KM at 26 mo median f/u
No MCR = 92%
p=0.037
MCR = 97% |
Silver, 200483
(Quality*)
CP, AP, BP |
|
AP: Relationship between MCR at 3 mo and 3-yr survival:
MCR at 3 mo - 85% 3-yr OS
No MCR - 52% 3-yr OS
p<0.001
CP: Relationship between at least a MinorCR at 6 mos and 3-yr survival:
MinorCR at 6 mo - 96% 3-yr OS
No MinorCR at 6 mo - 86% 3-yr OS
p<0.001 |
Karntarjian, Cortes, et al., 200472
(Quality 5/6)
CP-IFN-r |
Relationship between Major or Minor CR and 4-yr PFS:
CR = 93%
No CR = 55%
p<0.0001
Relationship between Major CR at 6 mo and 4-yr PFS:
CR = 94%
No CR = 51%
p<0.0001 |
Relationship between MCR or MinorCR and 4-yr OS:
CR = 95%
No CR = 72%
p<0.0001
Relationship between MCR or MinorCR at 6 mo and 4-yr OS:
CR = 96%
No CR = 70%
p<0.0001
In multivariate analysis, MinorCR or MCR at 3 and 6 mo predict survival (p=0.03 and 0.01, respectively). |
*Guilhot, 200462
(Quality*)
CP-new diagnosis |
Relationship between MCR at 6 mo and 30-mo PFS:
MCR at 6 mo (n=407) - 97%
No MCR at 6 mo (n=124) - 89%
p<0.001 |
Relationship between MCR at 6 mo and 30-mo OS:
MCR at 6 mo (n=407) - 97%
No MCR at 6 mo (n=124) - 92%
p=0.0162 |
Marin, Marktel, Bua, et al., 200375
(Quality 2/5)
CP |
Relationship to PFS (described in terms of % of Ph+ metaphases at 3 months):
Ph+ 0-65% (Minor CR + MCR): N= 52 83%
p=<0.0001
Ph+ > 65% (No CR): N = 88 32% |
Relationship to OS:
Ph+ 0-65%: N= 52 96%
p=<0.0001
Ph+ >65%: N = 88 52% |
| Change in CD34+ cells in the bone marrow |
*Marin, 2004100
(Quality*)
CP |
Degree of reduction of CD34+ cells—RR for PFS = 0.88
(CI 0.53-0.93)
p=0.006 |
|
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