Technology Assessment: Report on the Relative Efficacy of Oral Cancer Therapy for Medicare Beneficiaries Versus Currently Covered Therapy, Part 2. Imatinib for Gastrointestinal Stromal Tumors (GISTs). Table 9

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Table 9. Radiological Predictors of Disease Response or Survival

Characteristic	Factor	Studies Indicating an Association and Quality	Strength of Association with Tumor Response
PET	Evidence of response on Day 8 PET	Stroobants, et al., 2003 quality = 4/6)⁶¹	1 year PFS: Positive evidence of response on PET at 8 days PFS = 92%, No response to PET at 8 days PFS = 12%, p = 0.00107
PET vs CT (RECIST)	Differential ability to predict response to imatinib (by month of assessment)	Antoch, et al., 2004 (quality = 5/5)⁶²	PET 1 mo 85% 3 mo 100% 6 mo 100% CT 1 mo 44% 3 mo 60% 6 mo 57% Combined PET/CT 1 mo 95% 3 mo 100% 6 mo 100% Side-by-side PET and CT 1 mo 90% 3 mo 100% 6 mo 100%
	Performance of F-FDG PET and CT in staging GISTS	Gayed, et al., 2004 (quality = 1/5)⁶³	Sensitivity: CT 93% PET 86% p = 0.27 Positive predictive value: CT 100% PET 98% p = 0.25
Angio-echography with BR-1 contrast vs. CT (RECIST)	Ability to predict clinical outcome and therapeutic effect of imatinib	De Giorgi et al., 2004 (abstract)⁶⁴	Documented tumor response: CT = 46% Angio-echography = 82%
Ultrasound with perfusion software and contrast injection vs. CT	Ability to predict clinical outcome and therapeutic effect of imatinib	Lassau, et al., 2004 (abstract)⁶⁵	No significant difference between CT and ultrasound's ability to document response

Abbreviations: PET = FDG positive emission tomography; CT = computed tomography; TTP = time to progression; OS = overall survival; EFS = event free survival; HR = hazard ratio; RECIST = RECIST response criteria—go to Table 2; NS = not significant

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