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Report on the Relative Efficacy of Oral Cancer Therapy for Medicare Beneficiaries Versus Currently Covered Therapy

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Part 1. Gefitinib and Erlotinib for Non-Small Cell Lung Cancer (continued)


Included Articles

AstraZeneca. Gefitinib (IRESSA™) marketing authorization application withdrawn in EU. 2005, January 4. Accessed at http://www.astrazeneca.com/pressrelease/4442.aspx on March 22, 2005.

Bailey LR, Janas M, Schmidt K, et al. Evaluation of epidermal growth factor receptor (EGFR) as a predictive marker in patients with non-small-cell lung cancer (NSCLC) receiving first-line gefitinib combined with platinum-based chemotherapy. Journal of Clinical Oncology 2004;22(14):013.

Barlesi F, Tchouhadjian C, Doddoli C, et al. CYFRA 21-1 level predicts survival in non-small-cell lung cancer patients receiving gefitinib as third-line therapy. British Journal of Cancer 2005;92(1):13-4.

Cappuzzo F, Ardizzoni A, Soto-Parra H, et al. Epidermal growth factor receptor targeted therapy by ZD 1839 (Iressa) in patients with brain metastases from non-small cell lung cancer (NSCLC). Lung Cancer 2003;41(2):227-31.

Cappuzzo F, Bartolini S, Ceresoli GL, et al. Efficacy and tolerability of gefitinib in pretreated elderly patients with advanced non-small-cell lung cancer (NSCLC). British Journal of Cancer 2004;90(1):82-6.

Cappuzzo F, Gregorc V, Rossi E, et al. Gefitinib in pretreated non-small-cell lung cancer (NSCLC): analysis of efficacy and correlation with HER2 and epidermal growth factor receptor expression in locally advanced or metastatic NSCLC. Journal of Clinical Oncology 2003;21(14):2658-63.

Cappuzzo F, Hirsch FR, Rossi E, et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. Journal of the National Cancer Institute 2005;97(9):643-55.

Cappuzzo F, Magrini E, Ceresoli GL, et al. Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. Journal of the National Cancer Institute 2004;96(15):1133-41.

Cappuzzo F, Varella-Garcia M, Shigematsu H, et al. Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients. Journal of Clinical Oncology 2005;23(22):5007-18.

Cella D, Herbst RS, Lynch TJ, et al. Clinically meaningful improvement in symptoms and quality of life for patients with non-small-cell lung cancer receiving gefitinib in a randomized controlled trial. Journal of Clinical Oncology 2005;23(13):2946-54.

Ceresoli GL, Cappuzzo F, Gregorc V, et al. Gefitinib in patients with brain metastases from non-small-cell lung cancer: a prospective trial. Annals of Oncology 2004;15(7):1042-7.

Clark GM, Zborowski D, Santabárbara P, et al. Smoking history is more predictive of survival benefit from erlotinib for patients with non-small cell lung cancer (NSCLC) than EGFR expression. 2005 ASCO Annual Meetings 2005; Abstract #7033.

Cortas T, Eisenberg R, Fu P, et al. Activation state (phosphorylated) EGFR and STAT3 as prognostic markers in resected non-small cell lung cancer (NSCLC). 2005 ASCO Annual Meetings 2005; Abstract #7090.

Cortes-Funes H, Almanza C, Valero P, et al. Epidermal growth factor receptor (EGFR)-activating mutations (mut) and response to gefitinib in lung adenocarcinoma. Journal of Clinical Oncology 2005;23(16s):Abstract #7076.

Cortes-Funes H, Almanza C, Valero P, et al. Epidermal growth factor receptor (EGFR)-activating mutations (mut) and response to gefitinib in lung adenocarcinoma. 2005 ASCO Annual Meetings 2005; Abstract #7076.

Cortes-Funes H, Soto Parra H. Extensive experience of disease control with gefitinib and the role of prognostic markers. British Journal of Cancer 2003;89(Suppl 2):S3-8.

D'Addario G, Rauch D, Stupp R, et al. Multicenter phase II trial of gefitinib first-line therapy followed by chemotherapy in advanced non-small cell lung cancer (NSCLC)—preliminary results. A study of the Swiss Group for Clinical Cancer Research (SAKK). 2005 ASCO Annual Meetings 2005; Abstract #7128.

Dalziel K, Round A, Stein K, et al. The effectiveness and cost-effectiveness of Imatinib for first line treatment of chronic myeloid leukaemia in chronic phase. Accessed at http://www.ncchta.org/fullmono/mon828.pdf on November 14, 2005.

Dancey J, Shepherd FA, Gralla RJ, et al. Quality of life assessment of second-line docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy: results of a prospective, randomized phase III trial. Lung Cancer 2004;43:183-94.

DeGrendele H. Epidermal growth factor receptor inhibitors, gefitinib and erlotinib (Tarceva , OSI-774), in the treatment of bronchioloalveolar carcinoma. Clinical Lung Cancer 2003;5(2):83-5.

Dickson NR, Hainsworth JD, Spigel DR, et al. Single agent gefitinib in poor performance status patients with previously untreated advanced nonsmall cell lung cancer: A Minnie Pearl Cancer Research Network phase II trial. Journal of Clinical Oncology 2004;22(14):086.

Eberhard DA, Johnson BE, Amler LC, et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. Journal of Clinical Oncology 2005;23(25):5900-9.

Ervin TJ, Toothaker SR. Community practice experience with gefitinib (ZD1839) as treatment for patients with advanced non-small-cell lung cancer (NSCLC) within an expanded access clinical program. Journal of Clinical Oncology 2004;22(14):367.

Felip E, Rojo F, Heller A, et al. Phase II pharmacodynamic trial of erlotinib in advanced non-small cell lung cancer (NSCLC) patients previously treated with platinum-based chemotherapy: preliminary results. 2005 ASCO Annual Meetings 2005; Abstract #7100.

Fossella FV, DeVore R, Kerr RN, et al. Randomized phase III trial of docetaxel versus vinorelbine or ifosfamide in patients with advanced nonsmall-cell lung cancer previously treated with platinum-containing chemotherapy regimens. Journal of Clinical Oncology 2000;18(12):2354-62.

Franklin WA, Chansky K, Gumerlock PH, et al. Association between activation of ErbB pathway genes and survival following gefitinib treatment in advanced BAC (SWOG 0126). Journal of Clinical Oncology 2004;22(14):015.

Fujiwara Y, Kiura K, Toyooka S, et al. Effect of epidermal growth factor receptor gene mutations on adverse events of gefitinib in patients with non-small cell lung cancer. 2005 ASCO Annual Meetings 2005; Abstract #7096.

Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. Journal of Clinical Oncology 2003;21(12):2237-46.

Gatzemeier U, Heller A, Foernzler D, et al. Exploratory analyses EGFR, kRAS mutations and other molecular markers in tumors of NSCLC patients (pts) treated with chemotherapy +/- erlotinib (TALENT). 2005 ASCO Annual Meetings 2005; Abstract #7028.

Giaccone G, Herbst RS, Manegold C, et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 1. Journal of Clinical Oncology 2004;22(5):777-84.

Giaccone G, Lechevalier T, Thatcher N, et al. A phase II study of Erlotinib as first-line treatment of advanced non-small cell lung cancer. 2005 ASCO Annual Meetings 2005; Abstract #7073.

Goto K, Kim E, Kubota K, et al. Association of multiple pulmonary metastases with response to gefitinib in patients with non-small cell lung cancer. Journal of Clinical Oncology 2004;22(14):098.

Gridelli C, Maione P, Castaldo V, et al. Gefitinib in elderly and unfit patients affected by advanced non-small-cell lung cancer. British Journal of Cancer 2003;89(10):1827-9.

Gridelli C, Rossi A, Maione P, et al. Gefitinib as salvage therapy in pretreated patients with advanced non-small cell lung cancer. Data from a compassionate use program. Anticancer Research 2004;24(3b):1873-7.

Gumerlock PH, Holland WS, Chen H, et al. Mutational analysis of K-RAS and EGFR implicates K-RAS as a resistance marker in the Southwest Oncology Group (SWOG) trial S0126 of bronchioalveolar carcinoma (BAC) patients (pts) treated with gefitinib. 2005 ASCO Annual Meetings 2005; Abstract #7008.

Han SW, Hwang PG, Chung DH, et al. Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer. International Journal of Cancer 2005;113(1):109-15.

Han SW, Hwang PG, Chung DH, et al. Gefitinib monotherapy in previously treated advanced non-small cell lung cancer (NSCLC): An immunohistochemical (IHC) analysis of EGFR and its downstream molecules. Journal of Clinical Oncology 2004;22(14):096.

Han SW, Jeong S, Choi IS, et al. EGFR and K-ras mutations as determinants of gefitinib sensitivity in non-small-cell lung cancer (NSCLC). 2005 ASCO Annual Meetings 2005; Abstract #7078.

Han SW, Kim TY, Hwang PG, et al. Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib. Journal of Clinical Oncology 2005;23(11):2493-501.

Hanna N, Shepherd FA, Fossella FV, et al. Randomized phase III trial of pemetrexed versus docetaxel in patients with nonsmall-cell lung cancer previously treated with chemotherapy. Journal of Clinical Oncology 2004;22(9):1589-97.

Herbst RS, Giaccone G, Schiller JH, et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 2. Journal of Clinical Oncology 2004;22(5):785-94.

Hirsch FR, Gandara DR, McCoy J, et al. Increased EGFR gene copy number detected by FISH is associated with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma (BAC) (S0126). 2005 ASCO Annual Meetings 2005; Abstract #7030.

Hirsch F, Varella-Garcia M, McCoy J, et al. Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group study. Journal of Clinical Oncology 2005;23(28):6838-45.

Hotta K, Kiura K, Ueoka H, et al. Effect of gefitinib ('Iressa', ZD1839) on brain metastases in patients with advanced non-small-cell lung cancer. Lung Cancer 2004;46(2):255-61.

Hotta K, Matsuo K, Ueoka H, et al. Continued gefitinib treatment after disease stabilization prolongs survival of patients with advanced non-small-cell lung cancer. 2005 ASCO Annual Meetings 2005; Abstract #7088.

Huang SF, Liu HP, Li LH, et al. High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. Clinical Cancer Research 2004;10(24):8195-203.

Hussain S, Zakowski MF, Kris MG, et al. Correlation of EGFR and KRAS mutation status, response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors and survival with histologic subtypes of adenocarcinoma of the lung. 2005 ASCO Annual Meetings 2005; Abstract #7080.

Jackman D, Lucca J, Fidias P, et al. Phase II study of the EGFR tyrosine kinase erlotinib in patients > 70 years of age with previously untreated advanced non-small cell lung carcinoma. 2005 ASCO Annual Meetings 2005; Abstract #7148.

Janas M, Bailey LR, Schmidt K, et al. Evaluation of epidermal growth factor receptor (EGFR) as a prognostic factor for survival in non-small-cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy as first-line treatment. Journal of Clinical Oncology 2004;22(14): 024.

Janne PA, Gurubhagavatula S, Yeap BY, et al. Outcomes of patients with advanced non-small cell lung cancer treated with gefitinib (ZD1839, "Iressa") on an expanded access study. Lung Cancer 2004;44(2):221-30.

Kasahara K, Kimura H, Yoshimoto A, et al. A phase II study of gefitinib monotherapy for chemotherapy-naive patients with non-small cell lung cancer. 2005 ASCO Annual Meetings 2005; Abstract #7074.

Kawada I, Soejima K, Watanabe H, et al. Quick screening of EGFR mutation using restriction fraction length polymorphism. 2005 ASCO Annual Meetings 2005; Abstract #7071.

Kim KS, Jeong JY, Kim YC, et al. Predictors of the response to gefitinib in refractory non-small cell lung cancer. Clinical Cancer Research 2005;11(6):2244-51.

Kim YH, Goto K, Ishii G, et al. Association of papillary subtype of lung adenocarcinoma with response to gefitinib. Journal of Clinical Oncology 2004;22(14):092.

Kishi K, Homma S, Miyamoto A, et al. Factors predicting the efficacy of gefitinib in patients with advanced non-small cell lung cancer (NSCLC). 2005 ASCO Annual Meetings 2005; Abstract #7095.

Kris MG, Natale RB, Herbst RS, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 2003;290(16):2149-58.

Kris MG, Sandler A, Miller V, et al. Cigarette smoking history predicts sensitivity to erlotinib: Results of a phase II trial in patients with bronchioloalveolar carcinoma (BAC). Journal of Clinical Oncology 2004;22(14):062.

Kris MG, Sandler A, Miller VA, et al. EGFR and KRAS mutations in patients with bronchioloalveolar carcinoma treated with erlotinib in a phase II multicenter trial. 2005 ASCO Annual Meetings 2005; Abstract #7029.

Lee DH, Han JY, Lee HG, et al. A phase II study of gefitinib as a first-line therapy of advanced or metastatic adenocarcinoma of the lung in lifetime non-smokers. 2005 ASCO Annual Meetings 2005; Abstract #7072.

Lynch TJ, Bell D, Haber D, et al. Correlation of molecular markers including mutations with clinical outcomes in advanced non small cell lung cancer (NSCLC) patients (pts) treated with gefitinib, chemotherapy or chemotherapy and gefitinib in IDEAL and INTACT clinical trials. 2005 ASCO Annual Meetings 2005; Abstract #7006.

Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. New England Journal of Medicine 2004;350(21):2129-39.

Massarelli E, Andre F, Liu DD, et al. A retrospective analysis of the outcome of patients who have received two prior chemotherapy regimens including platinum and docetaxel for recurrent non-small-cell lung cancer. Lung Cancer 2003;39:55-61.

Matsuura K, Kudoh S, Mitsuoka S, et al. Evaluating a prognostic factor in advanced adenocarcinoma of the lung who have treated with gefitinib. Journal of Clinical Oncology 2004;22(14):334.

Mey U, Flieger D, Birkmann J, et al. Salvage treatment for patients with refractory or relapsed aggressive non-Hodgkin's lymphoma with dexamethasone, high-dose cytarabine, and cisplatin (DHAP) in combination with rituximab: preliminary results of a multicenter phase II trial. Accessed at http://www.abstracts2view.com/hemphiladelphia02/view.php?nu=HEM2L_2241 on November 14, 2005.

Miller VA, Herbst RS, Prager D, et al. Long survival of never smoking non-small cell lung cancer (NSCLC) patients (pts) treated with erlotinib HCl (OSI-774) and chemotherapy: Sub-group analysis of TRIBUTE. Journal of Clinical Oncology 2004;22(14S):7061.

Miller VA, Kris MG, Shah N, et al. Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer. Journal of Clinical Oncology 2004;22(6):1103-9.

Miller VA, Zakowski M, Riely GJ, et al. EGFR mutation, immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH) as predictors of sensitivity to erlotinib and gefitinib in patients (pts) with NSCLC. 2005 ASCO Annual Meetings 2005; Abstract #7031.

Milton DT, Miller VA, Azzoli CG, et al. Weekly high-dose erlotinib in patients with non-small cell lung cancer (NSCLC): A phase I/II study. Journal of Clinical Oncology 2004;22(14):085.

Mitsudomi T, Kosaka T, Endoh H, et al. Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. Journal of Clinical Oncology 2005;23(11):2513-20.

Mohamed MK, Ramalingam S, Lin Y, et al. Skin rash and good performance status (PS) predict improved survival with gefitinib for patients with advanced non-small cell lung cancer (NSCLC). Journal of Clinical Oncology 2004;22(14):097.

Mu XL, Li LY, Zhang XT, et al. Evaluation of safety and efficacy of gefitinib ('iressa', zd1839) as monotherapy in a series of Chinese patients with advanced non-small-cell lung cancer: experience from a compassionate-use programme. BMC Cancer 2004;4(1):51.

Niho S, Kubota K, Goto K, et al. First-line single agent of gefitinib in patients (pts) with advanced non-small cell lung cancer (NSCLC): A phase II study. Journal of Clinical Oncology 2004;22(14):059.

Ochs J, Grous JJ, Warner KL. Final survival and safety results for 21,064 non-small-cell lung cancer (NSCLC) patients who received compassionate use gefitinib in a U.S. expanded access program (EAP). Journal of Clinical Oncology 2004;22(14):060.

Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304:1497-50.

Pallis AG, Mavroudis D, Androulakis N, et al. ZD1839, a novel, oral epidermal growth factor receptor-tyrosine kinase inhibitor, as salvage treatment in patients with advanced non-small cell lung cancer. Experience from a single center participating in a compassionate use program. Lung Cancer 2003;40(3):301-7.

Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 2004;101(36):13306-11.

Pao W, Wang TY, Riely GJ, et al. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med 2005;2(1):e17.

Pao W, Zakowski M, Cordon-Cardo C, et al. Molecular characteristics of non-small cell lung cancer (NSCLC) patients sensitive to gefitinib. Journal of Clinical Oncology 2004;22(14):025.

Parra HS, Cavina R, Latteri F, et al. Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib ('Iressa', ZD1839) in non-small-cell lung cancer. British Journal of Cancer 2004;91(2):208-12.

Parton M, Maisey N, Banerjee S, et al. Gefitinib in patients with non-small cell lung cancer (NSCLC): The Royal Marsden experience. Journal of Clinical Oncology 2004;22(14):099.

Perez-Soler R. Can rash associated with HER1/EGFR inhibition be used as a marker of treatment outcome? Oncology (Huntington) 2003;17(11 Suppl 12):23-8.

Perez-Soler R. Phase II clinical trial data with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (OSI-774) in non-small-cell lung cancer. Clinical Lung Cancer 2004;6(Suppl 1):S20-3.

Perez-Soler R, Chachoua A, Hammond LA, et al. Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer. Journal of Clinical Oncology 2004;22(16):3238-47.

Polowy C, Coon J, Villaflor V, et al. Potential molecular prognostic factors in non-small cell lung cancer (NSCLC) patients treated with gefitinib. Journal of Clinical Oncology 2004;22(14):089.

Reck M, Gatzemeier U, Bucholz E, et al. An open-label, multi centre, phase II, non-comparative trial of ZD1839 monotherapy in chemotherapy-naive patients with stage IV or stage III non-operable non-small cell lung cancer (NSCLC). 2005 ASCO Annual Meetings 2005; Abstract #7098.

Reiling RB, Natale R, Wade J, et al. Efficacy and safety of gefitinib in chemo-naive patients with non-small cell lung cancer (NSCLC) in an Expanded Access Program (EAP). 2005 ASCO Annual Meetings 2005; Abstract #22650.

Reiling RB, Wade JL, Govindan R, et al. Clinical benefit with compassionate use gefitinib in a subset of non-small-cell lung cancer (NSCLC) patients with the bronchoalveolar (BAC) subtype treated during an expanded access program (EAP). Journal of Clinical Oncology 2004;22(14):087.

Roszkowski K, Pluzanska A, Krzakowski M, et al. A multicenter, randomized, phase III study of docetaxel plus best supportive care versus best supportive care in chemotherapy-naive patients with metastatic or non-resectable localized non-small cell lung cancer (NSCLC). Lung Cancer 2000;27:145-57.

Santo A, Salmaso F, Giovannini M, et al. Gefitinib (ZD1839) as compassionate use therapy in patients (pts) with advanced non-small-cell lung-cancer (NSCLC) after failing prior chemotherapy. Journal of Clinical Oncology 2004;22(14):324.

Santoro A, Cavina R, Latteri F, et al. Activity of a specific inhibitor, gefitinib (Iressa, ZD1839), of epidermal growth factor receptor in refractory non-small-cell lung cancer. Annals of Oncology 2004;15(1):33-7.

Seto T, Yamamoto N. Interstitial lung diseases (ILD) induced by gefitinib in patients with advanced non-small cell lung cancer (NSCLC): Results of a West Japan Thoracic Oncology Group (WJTOG) epidemiological survey. Journal of Clinical Oncology 2004;22(14):064.

Shepherd FA, Dancey J, Ramlau R, et al. Prospective randomized trial of docetaxel versus best supportive care in patients with nonsmall-cell lung cancer previously treated with platinum-based chemotherapy. Journal of Clinical Oncology 2000;18(10):2095-103.

Shepherd FA, Pereira J, Ciuleanu TE, et al. A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) following failure of 1st line or 2nd line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial. Journal of Clinical Oncology 2004;22(14S):7022.

Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. New England Journal of Medicine 2005;353(2):123-32.

Simon GR, Ruckdeschel JC, Williams C, et al. Gefitinib (ZD1839) in previously treated advanced non-small-cell lung cancer: experience from a single institution. Cancer Control 2003;10(5):388-95.

Soulieres D. Identifying predictive and surrogate markers of erlotinib antitumor activity other than rash. Oncology (Huntington) 2003;17(11 Suppl 12):29-33.

Spaeth D, Deplanque G, Favrot N, et al. Gefitinib in heavily pretreated non small cell lung cancer: Results of the expanded access program in Eastern France. Journal of Clinical Oncology 2004;22(14):323.

Suzuki R, Hasegawa Y, Baba K, et al. A phase II study of first-line single agent of gefitinib in patients (pts) with stage IV non-small cell lung cancer (NSCLC). 2005 ASCO Annual Meetings 2005; Abstract #7082.

Takano T, Ohe Y, Kusumoto M, et al. Risk factors for interstitial lung disease and predictive factors for tumor response in patients with advanced non-small cell lung cancer treated with gefitinib. Lung Cancer 2004;45(1):93-104.

Takano T, Ohe Y, Yoshida T, et al. Evaluation of epidermal growth factor receptor (EGFR) mutations and gene copy numbers as predictors of clinical outcomes in Japanese patients with recurrent non-small-cell lung cancer (NSCLC) receiving gefitinib. 2005 ASCO Annual Meetings 2005; Abstract #7032.

Taron M, Ichinose Y, Rosell R, et al. Epidermal growth factor receptor (EGFR) activating mutations (muts) in the tyrosine kinase (TK) domain correlate with gefitinib response in chemorefractory non-small-cell lung cancer (NSCLC). 2005 ASCO Annual Meetings 2005; Abstract #7087.

Tokumo M, Toyooka S, Kiura K, et al. The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers. Clinical Cancer Research 2005;11(3):1167-73.

Tsai C, Chiu C, Chou T, et al. Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non-small cell lung cancer. 2005 ASCO Annual Meetings 2005; Abstract #7086.

Tsao MS, Sakurada A, Cutz JC, et al. Erlotinib in lung cancer - molecular and clinical predictors of outcome. New England Journal of Medicine 2005;353(2):133-44.

Tsao MS, Sakurada A, Lorimer I, et al. Molecular analysis of the epidermal growth factor receptor (EGFR) gene and protein expression in patients treated with erlotinib in National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial BR.21. 2005 ASCO Annual Meetings 2005; Abstract #7007.

Villaflor VM, Buckingham L, Gale M, et al. EGFR mutations and pAKT expression as potential predictors of gefitinib efficacy in non-small cell lung cancer (NSCLC) patients (pts). 2005 ASCO Annual Meetings 2005; Abstract #7077.

Villaflor VM, Polowy CR, Coon JS, et al. Potential clinical prognostic factors in non-small cell lung cancer (NSCLC) patients treated with gefitinib. Journal of Clinical Oncology 2004;22(14):088.

West H, Franklin WA, Gumerlock PH, et al. Gefitinib (ZD1839) therapy for advanced bronchioloalveolar lung cancer (BAC): Southwest Oncology Group (SWOG) Study S0126. Journal of Clinical Oncology 2004;22(14):014.

Wilkinson E. Surprise phase III failure for ZD1839. Lancet Oncology 2002;3(10):583.

Williams CC, Haura EB, Antonia SJ, et al. Phase II trial of docetaxel and gefitinib as first-line therapy for elderly patients with advanced nonsmall cell lung cancer (ANSCLC). Journal of Clinical Oncology 2004;22(14S):Abstract #7342.

Wu YL, Yang X, Yang J-J, et al. ZD1839 for the treatment of heavily pretreated non-small cell lung cancer. Journal of Clinical Oncology 2004;22(14):341.

Zhang X-T, Li L. Evaluation of safety and efficacy of ZD1839 as monotherapy for Chinese patients with advanced non-small cell lung cancer. Journal of Clinical Oncology 2004;22(14):093.

Zinner R, Govindan R, Wozniak AJ, et al. Compassionate use experience with gefitinib in poor performance (PS) patients with advanced nonsmall-cell lung cancer (NSCLC) treated in an expanded access program (EAP). 22. 2004:Abstract #7082.

Zinner R, Govindan R, Wozniak AJ, et al. Compassionate use experience with gefitinib in poor performance (PS) patients with advanced nonsmall-cell lung cancer (NSCLC) treated in an expanded access program (EAP). Journal of Clinical Oncology 2004;22(14):082.

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