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Table 13. Patient Characteristics Predictive of Survival, TTP, or Response Among EGFR Inhibitor Studies
| Characteristic |
Favorable Prognostic Factor |
No. of studies indicating an association with response |
References |
No. of studies indicating an association with survival |
References |
| Sex |
Female vs. male |
7/13 |
13,25,29-31,38,48-54 |
4/7 |
18,25,38,55-58 |
| Performance status |
PS 0/1 vs. PS 2 or KPS > or = 80
vs. < or = 70 |
1/7 |
13,25,29,30,53,59,60 |
10/11 |
6,7,25,31,54,56,57,61-63 |
| Smoking status |
Never vs. former/current |
11/15 |
13,19,25,38,48-53,60,63-66 |
6/7 |
8,25,26,38,61,65,67 |
| Prior chemo |
Yes vs. no or number of prior regimens |
1/6 |
29,31,52,53,59,66 |
- - |
- - |
| Age |
> 70 vs. < or = 70 years |
2/6 |
25,29,31,60,66,68 |
0/2 |
25,68 |
| Rash |
Any vs. none |
0/3 |
31,38,48 |
7/8 |
6,18,31,38,46,57,62,69 |
| Stage of disease |
IIIB vs. IV |
0/3 |
13,31,59 |
1/1 |
55 |
| |
I-IV vs. recurrent |
0/1 |
60 |
- - |
- - |
| Ethnicity |
East Asian vs. non-East Asian |
2/3 |
25,30,66 |
3/3 |
25,26,55 |
| Prior immuno/hormonal therapy |
Yes vs. none |
1/1 |
30 |
- - |
- - |
| Hypertransaminasemia |
|
1/1 |
38 |
1/1 |
38 |
| Bone or liver metastasis |
|
0/1 |
53 |
2/2 |
6,7 |
| Pulmonary metastases |
> 6 vs. < or = 6 |
1/1 |
64 |
- - |
- - |
| Brain metastases |
|
0/1 |
60 |
- - |
- - |
| Prior XRT to chest |
No vs. yes |
1/1 |
38 |
- - |
- - |
| Prior cisplatin or carboplatin |
Yes vs. no |
0/2 |
25,53 |
0/1 |
25 |
| Prior docetaxel |
Yes vs. no |
0/1 |
53 |
- - |
- - |
| Time since last chemo |
< 6 vs. > or = 6 mos. |
1/1 |
31 |
- - |
- - |
| Time since diagnosis |
- - |
0/1 |
29 |
1/1 |
31 |
| Weight loss |
- - |
- - |
- - |
2/2 |
67 |
| Diarrhea |
- - |
- - |
- - |
1/1 |
38 |
Abbreviations: chemo = chemotherapy; EGFR = epidermal growth factor receptor; KPS = Karnofsky performance status; No. = number; PS = performance status; TTP = time to progression; XRT = radiation therapy.
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