Skip Navigation U.S. Department of Health and Human Services www.hhs.gov
Agency for Healthcare Research Quality www.ahrq.gov
Archive print banner

This information is for reference purposes only. It was current when produced and may now be outdated. Archive material is no longer maintained, and some links may not work. Persons with disabilities having difficulty accessing this information should contact us at: https://info.ahrq.gov. Let us know the nature of the problem, the Web address of what you want, and your contact information.

Please go to www.ahrq.gov for current information.

Table 13. Patient Characteristics Predictive of Survival, TTP, or Response Among EGFR Inhibitor Studies

Characteristic Favorable Prognostic Factor No. of studies indicating an association with response References No. of studies indicating an association with survival References
Sex Female vs. male 7/13 13,25,29-31,38,48-54 4/7 18,25,38,55-58
Performance status PS 0/1 vs. PS 2 or KPS > or = 80
vs. < or = 70
1/7 13,25,29,30,53,59,60 10/11 6,7,25,31,54,56,57,61-63
Smoking status Never vs. former/current 11/15 13,19,25,38,48-53,60,63-66 6/7 8,25,26,38,61,65,67
Prior chemo Yes vs. no or number of prior regimens 1/6 29,31,52,53,59,66 - - - -
Age > 70 vs. < or = 70 years 2/6 25,29,31,60,66,68 0/2 25,68
Rash Any vs. none 0/3 31,38,48 7/8 6,18,31,38,46,57,62,69
Stage of disease IIIB vs. IV 0/3 13,31,59 1/1 55
  I-IV vs. recurrent 0/1 60 - - - -
Ethnicity East Asian vs. non-East Asian 2/3 25,30,66 3/3 25,26,55
Prior immuno/hormonal therapy Yes vs. none 1/1 30 - - - -
Hypertransaminasemia   1/1 38 1/1 38
Bone or liver metastasis   0/1 53 2/2 6,7
Pulmonary metastases > 6 vs. < or = 6 1/1 64 - - - -
Brain metastases   0/1 60 - - - -
Prior XRT to chest No vs. yes 1/1 38 - - - -
Prior cisplatin or carboplatin Yes vs. no 0/2 25,53 0/1 25
Prior docetaxel Yes vs. no 0/1 53 - - - -
Time since last chemo < 6 vs. > or = 6 mos. 1/1 31 - - - -
Time since diagnosis - - 0/1 29 1/1 31
Weight loss - - - - - - 2/2 67
Diarrhea - - - - - - 1/1 38

Abbreviations: chemo = chemotherapy; EGFR = epidermal growth factor receptor; KPS = Karnofsky performance status; No. = number; PS = performance status; TTP = time to progression; XRT = radiation therapy.

Return to Document

The information on this page is archived and provided for reference purposes only.

 

AHRQ Advancing Excellence in Health Care