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Table 16. Association of EGFR Mutation With Response to Gefitinib

Study name Direction Responses/Total Responses/Total Statistics for each study p-value
Mutation Wild type Risk
ratio
Lower
limit
Upper
limit
Paez, et al. 200484 Case-control 5/5 0/4 9.2 0.7 128.5 0.1001
Jackman, et al. 200521 Cohort 3/5 2/23 6.9 1.5 31.1 0.0119
Kim, et al. 200548 Cohort 6/6 2/21 8.2 2.5 26.7 0.0005
Pao, et al. 200483 Case-control 7/7 3/8 2.4 1 5.6 0.0397
Huang, et al. 200485 Case-control 7/8 2/8 3.5 1 12 0.0456
Lynch, et al. 200482 Case-control 8/8 6/8 5.7 1.3 24.6 0.0207
Kawada, et al. 200590 Cohort 8/8 6/13 8.8 1.9 40.3 0.005
Tokumo, et al. 200586 Case-control 8/9 2/12 5.3 1.5 19.3 0.0107
Cortes-Funes, et al. 200587 Cohort 8/10 6/73 9.7 4.3 22.3 0
Fujiwara, et al. 200595 Cohort 7/11 3/15 3.2 1.1 9.6 0.0403
Kris, et al. 200591 Cohort 10/13 3/37 9.5 3.1 29.2 0.0001
Han, et al. 2005 (2)89 Cohort 8/13 6/46 4.7 2 11.2 0.0004
Lynch (IDEAL) 200592 Cohort 6/13 6/61 4.7 1.8 12.3 0.0016
Kasahara, et al. 200513 Cohort 12/14 4/13 2.8 1.2 6.5 0.0172
Villaflor, et al. 200570 Cohort 9/14 3/44 9.4 3 30.1 0.0002
Taron, et al. 200566 Cohort 16/17 6/51 8 3.7 17.1 0
Han, et al. 200551 Cohort 11/17 10/73 4.7 2.4 9.3 0
Lynch (INTACT) 200592 Cohort 13/18 84/152 1.3 0.9 1.8 0.1014
Tsao (BR.21) 200542 Cohort 3/19 6/81 2.1 0.6 7.8 0.2512
Mitsudomi, et al. 200549 Cohort 24/29 2/21 8.7 2.3 32.8 0.0014
Tsai, et al. 200593 Cohort 22/29 10/25 1.9 1.1 3.2 0.0163
Takano, et al. 200550 Cohort 33/39 3/27 7.6 2.6 22.3 0.0002

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