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Table 11a. Predictors of Disease Response or Survival—Tumor Characteristics Related to the Potential Mechanism of Thalidomide Action: Summary
Prognostic Factor |
Number of studies indicating significant correlation with tumor response/ total number of studies indicating factor |
Number of studies indicating significant correlation with survival/ total number of studies indicating factor |
| BM Microvascular Density
|
Equivocal 1/1
(Singhal, 199935)
|
|
| Serum mucin-1 (sMUC-1)
|
No correlation=1/1
(Mileshkin, Prince, et al., 2003127)
|
No correlation=1/1
(Mileshkin, Prince, et al., 2003127)
|
| Fibroblast Growth Factor (FGF)
|
Some correlation with response=2/4
(Dmoszynska, 2002128; Neben, Moehler, Egerer, et al., 200152) No correlation=2/4
(Neben, Moehler, Kraemer, et al., 2001129; Tosi, 200257)
|
|
| Hepatocyte growth factor (HGF)
|
Correlation with response=1/1
(Neben, Moehler, Kraemer, et al., 2001129)
|
|
| Interleukin-6 (IL-6)
|
Some correlation with response=2/3
(Dmoszynska, 2002128; Thompson, 2003130) No correlation=1/3
(Neben, Moehler, Kraemer, et al., 2001129)
|
|
| Tumor necrosis factor alpha (TNFα)
|
Some correlation with response=2/3
(Dmoszynska, 2002128; Thompson, 2003130) No correlation=1/3
(Neben, Moehler, Kraemer, et al., 2001129)
|
|
| TNFα polymorphisms at position -238 of the gene promoter
|
Correlation with response=1/1
(Neben, Mytilineos, et al., 2002131)
|
Correlation with survival=1/1
(Neben, Mytilineos, et al., 2002131)
|
| TNFα polymorphisms at position -308 of the gene promoter
|
No correlation=1/1
(Neben, Mytilineos, et al., 2002131)
|
No correlation=1/1
(Neben, Mytilineos, et al., 2002131)
|
| t(4;14) positive multiple myeloma
|
Correlation with poor response to alkylating agents=1/1
(*Jaksic, 2004 (ASH 2417)132)
|
|
| Vascular Endothelial Growth Factor (VEGF)
|
Some correlation with response=2/4<
(Dmoszynska, 2002128; Tosi, 2002 57) No correlation=2/4
(Neben, Moehler, Egerer, et al., 200152; Neben, Moehler, Kraemer, et al., 2001129)
|
|
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Proceed to Table 11b
|
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