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Table 11a. Predictors of Disease Response or Survival—Tumor Characteristics Related to the Potential Mechanism of Thalidomide Action: Summary

Prognostic Factor

Number of studies indicating significant correlation with tumor response/ total number of studies indicating factor

Number of studies indicating significant correlation with survival/ total number of studies indicating factor

BM Microvascular Density

Equivocal 1/1
(Singhal, 199935)

 

Serum mucin-1 (sMUC-1)

No correlation=1/1
(Mileshkin, Prince, et al., 2003127)

No correlation=1/1
(Mileshkin, Prince, et al., 2003127)

Fibroblast Growth Factor (FGF)

Some correlation with response=2/4
(Dmoszynska, 2002128; Neben, Moehler, Egerer, et al., 200152)

No correlation=2/4
(Neben, Moehler, Kraemer, et al., 2001129; Tosi, 200257)

 

Hepatocyte growth factor (HGF)

Correlation with response=1/1
(Neben, Moehler, Kraemer, et al., 2001129)

 

Interleukin-6 (IL-6)

Some correlation with response=2/3
(Dmoszynska, 2002128; Thompson, 2003130)

No correlation=1/3
(Neben, Moehler, Kraemer, et al., 2001129)

 

Tumor necrosis factor alpha (TNFα)

Some correlation with response=2/3
(Dmoszynska, 2002128; Thompson, 2003130)

No correlation=1/3
(Neben, Moehler, Kraemer, et al., 2001129)

 

TNFα polymorphisms at position -238 of the gene promoter

Correlation with response=1/1
(Neben, Mytilineos, et al., 2002131)

Correlation with survival=1/1
(Neben, Mytilineos, et al., 2002131)

TNFα polymorphisms at position -308 of the gene promoter

No correlation=1/1
(Neben, Mytilineos, et al., 2002131)

No correlation=1/1
(Neben, Mytilineos, et al., 2002131)

t(4;14) positive multiple myeloma

Correlation with poor response to alkylating agents=1/1
(*Jaksic, 2004 (ASH 2417)132)

 

Vascular Endothelial Growth Factor (VEGF)

Some correlation with response=2/4<
(Dmoszynska, 2002128; Tosi, 2002 57)

No correlation=2/4
(Neben, Moehler, Egerer, et al., 200152; Neben, Moehler, Kraemer, et al., 2001129)

 

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