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Table 14a. Predictors of Disease Response or Survival—Thalidomide Dosage and Response Factors That Correlate With Overall Response to Thalidomide: Summary

Prognostic Factor

Number of studies indicating significant correlation with tumor response/ total number of studies indicating factor

Number of studies indicating significant correlation with survival/ total number of studies indicating factor

Cumulative 3-mo Thal dosage

Some correlation with response=1/2
(Yakoub-Agha, 200260)

No correlation=1/2
(Neben, Moehler, et al., 2002134)

Correlation with survival=2/2
(Neben, Moehler, et al., 2002134; Yakoub-Agha, 200260)

Change in paraprotein levels

Correlation with response=1/1
(Schey, 200355)

 

Relationship between paraprotein response and BM response

Correlation with response=1/1
(Singhal, 199935)

 

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