This information is for reference purposes only. It was current when produced and may now be outdated. Archive material is no longer maintained, and some links may not work. Persons with disabilities having difficulty accessing this information should contact us at: https://info.ahrq.gov. Let us know the nature of the problem, the Web address of what you want, and your contact information.
Please go to www.ahrq.gov for current information.
Addendum to Breastfeeding and Maternal and Infant Health Outcomes in Developed Countries1
It has been brought to our attention that Ranjit K Chandra may be involved in fraudulent publications.2,3 Dr. Chandra is an author of a primary study4 included in our update meta-analysis on the association of breastfeeding and asthma risk published in AHRQ Evidence Report Number 153.1 To assess the impact of this potentially fraudulent study, we repeated the meta-analysis by removing this study. Our original meta-analysis was conducted with and without a study that reported a very large adjusted odds ratio.5 Our re-analysis excluding Chandra 1991 and Wright 2001 (the one with the very large adjusted odds ratio) showed that the overall summary odds ratio remains significant (adjusted OR 0.63; 95%CI 0.45 - 0.89) (Figure 1). Our re-analysis excluding Chandra 1991 but including Wright 2001 showed that the overall summary odds ratio remains non-significant (adjusted OR 0.86; 95%CI 0.62 - 1.18) (Figure 2). These findings are similar to what were reported in the AHRQ Evidence Report. We conclude that excluding Chandra 1991 from our meta-analysis does not affect conclusions concerning breastfeeding and asthma risk made in the report.
Tufts Evidence-based Practice Center,
Tufts Medical Center,
1. Ip, S., Chung, M., Raman, G., Chew, P., Magula, N., DeVine, D., Trikalinos, T., and Lau,
J. Breastfeeding and Maternal and Infant Health Outcomes in Developed Countries. 153. 4-20-2007.
Rockville, MD, Agency for Healthcare Research and Quality. Evidence
Ref Type: Report
2. Roberts S. Dealing with scientific fraud: a proposal. Public Health Nutr 2006;9:664-65.
3. Sternberg S, Roberts S. Nutritional supplements and infection in the elderly: why do the
findings conflict? Nutr J 2006;5:30.
4. Chandra RK, Hamed A. Cumulative incidence of atopic disorders in high risk infants fed
whey hydrolysate, soy, and conventional cow milk formulas. Ann Allergy 1991;67:129-32.
5. Wright AL, Holberg CJ, Taussig LM, Martinez FD. Factors influencing the relation of
infant feeding to asthma and recurrent wheeze in childhood.[see comment]. Thorax
Current as of May 15, 2009