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Institution: University of Pennsylvania
Grant Title: Health
Preference Assessment in Parkinson's Disease
Grant Number: K08 HS00004
Total Award: $644,700
Project Description: The project had three main
- To produce a series of vignettes describing Parkinson's Disease
(PD)-related health states, and to elicit societal preference weights for these
- To conduct a cross sectional study comparing this set of
preferences to values derived from pre-scored multi-attribute health
classification systems, and to preferences elicited from patients and
- To conduct a longitudinal study to measure reliability and
responsiveness of preference-based measures in PD patients and their
Career Goals: Dr. Siderowf is an Associate Professor
of Neurology at the University of Pennsylvania School of Medicine. He
received his M.D. from Duke University and did his residency in neurology at the
Hospital of the University of Pennsylvania. He was then a Fellow in
Parkinson's Disease and Experimental Therapeutics at the University of
Rochester Medical School. During his K award period, Dr. Siderowf completed
the degree requirements for the Master of Science in Clinical Epidemiology. The
grantee has committed his career to bringing the methods of health services
research to the clinical area of Parkinson's Disease and related disorders.
Progress to Date: This grant has been
completed. Analysis of the data collected in the longitudinal study of
preference-based measures shows that directly elicited preferences (utilities)
vary substantially among Parkinson's patients, and are not strongly related to
measures of clinical disease severity. With the exception of the rating-scale
method, all directly elicited methods were difficult for patients to complete
and were received with skepticism. This was particularly true of the
willingness to pay exercise. In general, it appears that the pre-scored
instruments are more reliable and feasible in PD patients than the directly
elicited measures, with the exception of the rating scale method.
Highlights and Specific Accomplishments:
Panels and Committees by
Data Safety Monitoring Committee,
"Transcription and Therapy for Huntington's Disease (Steven M. Hersch, M.D.,
Ph.D., Principal Investigator, National Institute of Neurological Disorders and Stroke (NINDS) Program Project, Grant NS45242).
Symposium Committee; Parkinson Study Group.
- American Academy of Neurology.
- February 12, 2004, "Treatment
of Hyperkinetic Movement Disorders." Penn Neurology 2004 CME Course, San
- March 12, 2004,
"Follow-up Management after DBS." Philadelphia DBS Programming Seminar, Philadelphia.
- April 2, 2005, "Practical
Management of Parkinson's Disease." St. Joseph's Medical Center, Towson, MD.
- April 12, 2005,
"Update on Parkinson's Disease," Syracuse Community General Hospital, Syracuse, NY.
K-Generated Publications (selected):
Holloway R, Siderowf A.
Evidence-based neurotherapeutics: A spectrum of evidence. NeuroRx 2004.
Siderowf A. Evidence from clinical trials: Can we do better?
NeuroRx 2004. 1:363-71.
Lynch DR, Mozley PD, Sokol S, Maas NMC, Balcer LJ, Siderowf
AD. Lack of effect of polymorphisms in dopamine metabolism related genes on
imaging of TRODAT-1 in striatum of asymptomatic volunteers and patients with
Parkinson's Disease. Movement Disorders 2003. 18:804-11.
Siderowf A, Stern MB. Update on Parkinson's Disease. Annals of Internal Medicine 2003. 138;651-58.
Elman L, Siderowf A.
McCLuskey L. Nocturnal Oximetry: Utility in respiratory management of ALS.
Journal of Physical Medicine and Rehabilitation 2003. 82(11):866-70.
Cheng EM, Siderowf AM,
Swarztrauber K, Elisa M, Lee M, Vickrey BG. Development of quality of care
indicators for Parkinson's Disease. Movement Disorders 2004. 19(2):136-50.
Siderowf AM, Jaggi JL, Xie SX, et al. Long-term effects of
bilateral subthalamic nucleus stimulation on health-related quality of life in
advanced Parkinson's Disease. Movement Disorders 2006. 21(6):746-53
Ravina B, Putt, M, Siderowf
AD, et al. Donepezil for dementia in Parkinson's Disease: a randomized,
double blind, placebo controlled, crossover study. Journal of Neurology,
Neurosurgery, and Psychiatry 2005. 76:934-39.
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