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Table 2. Overview of high-risk studies1

Factor Carey(39) McDonald(38) Hauth(37) Morales(36) Vermuelen(35)
PTD <37 weeks, placebo 23% 35% 57% 39%  
GA (wk) at treatment 16-23 24 22-24 13-20 26
Treatment Oral metronidazole 2 g, repeat @ 48 hr Oral metronidazole 400 bid, 2 d Oral metronidazole 250 mg tid, 7 days, plus oral erythromycin 333 mg tid, 14 d Oral metronidazole 250 mg tid, 7 d Clindamycin 2% vaginal cream daily, 7 d
Second treatment All, 24-29 wk If positive test, 4 wk post-treatment If positive test, at 28 wk No second treatment All, 32 wk

[1] PTD, preterm delivery; GA, gestational age.

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