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Report on the Relative Efficacy of Oral Cancer Therapy for Medicare Beneficiaries Versus Currently Covered Therapy

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Table 15. Characteristics Predictive of Disease Response or Survival: Group 4—Other Factors

Prognostic factor Studies indicating an association and quality Strength of association with tumor response Strength of association with survival
Bone marrow cellularity Frater, 2003109
(Quality = 1/5)
BM cellularity 100% N =13 with decrease when responds to I  
Myelosuppression Sneed, 2003110
(Quality 5/6)
Any myelosuppression >Grade 3:
Yes (N=76) MCR 62% CCR 45%
No (N=67) MCR 78% CCR 64%

Any myelosuppression >Grade 3 for > 2wk duration:
Yes (N=50) MCR 58% CCR 36%
No (N=93) MCR 75% CCR 63%
Persistent BCR-ABL in CD34+ cells after CCR with I Bhatia, et al., 200327
(Quality = 2/5)
100% (N=15) had persistent evidence of BCR-ABL by FISH or RT-PCR up to 61 months (range 1-61) after starting I  
Evidence of BCR-ABL in CCR Paschka, 200310
(Quality = 4/6)
21/68 (31%) samples derived from pts in CCR by conventional cytogenetics have evidence of residual disease by HM-FISH

All (N=234) samples of CCR patients had evidence of BCR-ABL by RT-PCR
Abnormal cytogenetics in Ph- cells O'Dwyer, 200335
(Quality 2/5)
Clones with abnormal cytogenetics could be identified in the Ph- cells of 7 patients in MCR; link to disease outcome not presented  

Abbreviations: AP = Accelerated Phase; BC = Blast crisis; CP = Chronic Phase; CCR = complete cytogenetic response; I = Imatinib; MCR = Major cytogenetic response, Ph- = Philadelphia chromosome negative; pt(s) = patient(s)

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