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Addendum to Breastfeeding and Maternal and Infant Health Outcomes in Developed Countries1

It has been brought to our attention that Ranjit K Chandra may be involved in fraudulent publications.2,3 Dr. Chandra is an author of a primary study4 included in our update meta-analysis on the association of breastfeeding and asthma risk published in AHRQ Evidence Report Number 153.1 To assess the impact of this potentially fraudulent study, we repeated the meta-analysis by removing this study. Our original meta-analysis was conducted with and without a study that reported a very large adjusted odds ratio.5 Our re-analysis excluding Chandra 1991 and Wright 2001 (the one with the very large adjusted odds ratio) showed that the overall summary odds ratio remains significant (adjusted OR 0.63; 95%CI 0.45 - 0.89) (Figure 1). Our re-analysis excluding Chandra 1991 but including Wright 2001 showed that the overall summary odds ratio remains non-significant (adjusted OR 0.86; 95%CI 0.62 - 1.18) (Figure 2). These findings are similar to what were reported in the AHRQ Evidence Report. We conclude that excluding Chandra 1991 from our meta-analysis does not affect conclusions concerning breastfeeding and asthma risk made in the report.

Stanley Ip
Mei Chung
Joseph Lau

Tufts Evidence-based Practice Center,
Tufts Medical Center,
Boston, MA

Reference List

1. Ip, S., Chung, M., Raman, G., Chew, P., Magula, N., DeVine, D., Trikalinos, T., and Lau, J. Breastfeeding and Maternal and Infant Health Outcomes in Developed Countries. 153. 4-20-2007. Rockville, MD, Agency for Healthcare Research and Quality. Evidence Report/Technology Assessment. Ref Type: Report

2. Roberts S. Dealing with scientific fraud: a proposal. Public Health Nutr 2006;9:664-65.

3. Sternberg S, Roberts S. Nutritional supplements and infection in the elderly: why do the findings conflict? Nutr J 2006;5:30.

4. Chandra RK, Hamed A. Cumulative incidence of atopic disorders in high risk infants fed whey hydrolysate, soy, and conventional cow milk formulas. Ann Allergy 1991;67:129-32.

5. Wright AL, Holberg CJ, Taussig LM, Martinez FD. Factors influencing the relation of infant feeding to asthma and recurrent wheeze in childhood.[see comment]. Thorax 2001;56:192-97.

Current as of May 15, 2009


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