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Summaries of Independent Scientist (K) Awards

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Wyrwich, Kathleen

Institution: Saint Louis University
Grant Title: Population and Global Transition Assessments of HRQoL
Grant Number:  K02 HS011635
Duration: 5 years (2001-2006)
Total Award: $484,700

Project Description: This project had five main goals:

  1. Compare the three health related quality of life (HRQoL) measures in Healthy People 2010.
  2. Establish benchmarks for categorizing score ranges for these measures.
  3. Identify change over time in these measures to evaluate health interventions.
  4. Develop crosswalk score estimation methods between these measures and other widely used measures.
  5. Model underlying cognitive processes that patients employ when they assess their HRQol changes.

Career Goals: Dr. Wyrwich is Assistant Professor of Research Methodology in the College of Public Service at Saint Louis University.  She received her Ph.D. in Health Services Research also at Saint Louis University.

Progress to Date: This K02 has been successfully completed.  The research found that in general the HP2010 Leading Health Indicators reflect expected changes in Healthy Days (HDs).  Exceptions were seen with the Behavioral Risk Factor Surveillance System (BRFSS) items binge drinking and having a firearm nearby.

K-Generated Publications:  (selected)

Leidy NK, Wyrwich KW.  Bridging the gap: Using triangulation methodology to estimate minimal clinically important differences (MCIDs).  Journal of COPD 2005. 2:157-65.

Wyrwich, KW, Tierney WM, Babu AN, et al.  A comparison of clinically important differences in health-related quality of life for patients with chronic lung disease, asthma, or heart disease. Health Services Research 2005. 40(2):577-92.

Kroenke K, Wyrwich KW, Tierney WM, et al. Physician-estimated disease severity in patients with chronic heart or lung disease: A cross-sectional analysis. Health and Quality of Life Outcomes 2006. 4:60.

Wu HS, Wyrwich KW. Assessing fatigue in persons with cancer: Further validation of WuCancer Fatigue Scale. Journal of Pain and Symptom Management 2006. 32(3):255-65.

Wyrwich KW, Tardino VM. Understanding global transition assessments. Quality of Life Research 2006. 16(6):995-1004.

Wyrwich KW, Metz Sm, Kroenke K, et al. Interpreting quality of life data: Methods of community consensus in asthma. Annals of Allergy, Asthma, and Immunology 2006. 96(6).826-33.

Haughton K, Wyrwich KW, Brownson RC, et al. Individual, social, environmental, and physical environmental influences on physical activity among black and white adults: A structural equation approach. Annals of Behavioral Medicine 2006. 31(1):36-44.

Boehmer T, Hoehner CM, Wyrwich KW, et al. Correspondence between perceived and observed measures of neighborhood environmental supports for physical activity. Journal of Physical Activity and Health 2006. 3(1):22-36.

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