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Pediatric Terrorism and Disaster Preparedness

Public Health Emergency Preparedness

This resource was part of AHRQ's Public Health Emergency Preparedness program, which was discontinued on June 30, 2011, in a realignment of Federal efforts.

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Figure 4.7. Expected Smallpox Vaccination Site Reaction (i.e., a "take") in a First-time Vaccinate

Four photographs show the development of the pustule on a vaccination site: on Day 4, there are two small, pinkish blister-like formations (papule); by Day 7, there is a large, whitish pustule; by Day 14, this pustule has begun to dry up and heal; by Day 21, a scab has formed.

Note: Figure demonstrates the progression from papule (day 4) to pustule (days 7-14) to scab (day 21).

Source: Centers for Disease Control and Prevention. Available at

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